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P450 SNP Bioarray (GE Healthcare, US), DrugMet™ Genotyping Test (Jurilab Ltd., Finland), Tag-It™ Mutation Detection Kits (Tm Bioscience, Canada), and the Invader® CYP450 2D6 Analysis Panel (Third Wave Technologies Inc., US).6,12 None of these tests are licensed in Canada or the US. Rate of Technology Diffusion Your doctor may use cytochrome P450 (CYP450) tests to help determine how your body processes (metabolizes) a drug. The human body uses cytochrome P450 enzymes to process medications. Because of inherited (genetic) traits that cause variations in these enzymes, medications may affect each person differently.

Your doctor may use cytochrome P450 (CYP450) tests to help determine how your body processes (metabolizes) a drug. The human body contains P450 enzymes to process medications. As a result of inherited (genetic) traits that cause variations in these enzymes, medications may affect each person differently.

Background Information for Cytochrome P450 Genotyping Panel: Characteristics: The cytochrome P450 (CYP) isozymes 2C19, 2C8, 2C9, 2D6 and the CYP3A subfamily are involved in the metabolism of many drugs.Variants in the genes that code for CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, and CYP3A5 will influence pharmacokinetics of respective substrates, and may predict or explain non-standard dose. click to investigate

The Pillcheck test is optimized to maximize sensitivity and specificity (high resolution) and ensure accurate results for the ethnically diverse population in Canada. At a minimum, a clinical-grade test covers genetic markers (such as CYP2D6) and includes copy number variants (CNV).
Cytochrome P450 enzymes, notably CYP2C9, CYP2C19, and CYP2D6 are accountable for approximately 70% of drug metabolism in the body. Within the human body lies the cytochrome P450 enzymes, which are key components of both the synthesis and metabolism of molecules within a cell.
The cytochrome P450 inhibition assay is one of our portfolio of in vitro ADME screening services. Cyprotex deliver consistent, high quality data with cost-efficiency that comes from a highly automated approach. Inhibition of cytochrome P450 (CYP450) enzymes Cytochrome P450 Tests (CYP-2D6, 2C19 and 2C9) Introduction: The development of pharmacogenetics has resulted in clear explanations as to why some patients have serious side effects and other patients just don't respond to medications. It is estimated the genetics can account for 20 to 95 % of variability in drug disposition and effects.
Cytochrome 450 2D6 Genotype detects eight alleles associated with the poor metabolizer phenotype (PM). Patients with duplication of the CYP2D6 gene are ultraextensive metabolizers (UEM). Approximately 5-10% of Caucasian individuals express PM phenotype and the same percentage the UEM phenotype. Test Resources None found for this test see this page